Top 10 Best tylenol 325 mg in 2026

Last Updated - 7/1/2026

🏆Best Choice

Tylenol

Tylenol Extra Strength Acetaminophen Rapid Release Gels, Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes for Fast Release, Gentle on Stomach, 500 mg Per Gelcap, 100 Count OTC Medicine

9.8

ChoiceComparer.com Score

9.8

/ 10

Outstanding

Main highlights

•Fast-acting relief: Tylenol Extra Strength Rapid Release Gels feature 500 mg acetaminophen per gelcap to temporarily relieve minor aches and pains from headache, backache, arthritis, toothache, menstrual cramps, muscle aches, and fever; 100-count
•Rapid-release technology: Laser-drilled holes in each gelcap release acetaminophen faster for extra strength pain relief; gelcaps are gentle on the stomach and suitable for adults and children 12 years and older
•Multi-symptom support: Use as a fever reducer and to relieve headache, backache, muscle aches, arthritis pain, toothache, and joint discomfort; also helps with menstrual and premenstrual cramps and pain from the common cold or flu
•Dosage instructions: Adults and children 12 years and older take two gelcaps every six hours while symptoms last; do not exceed six gelcaps in 24 hours; always follow the label directions for safe use of acetaminophen and dosing guidance
•Doctor-recommended brand: Choose Tylenol, the #1 doctor-recommended brand for pain relief and fever reduction based on 2021 IQVIA survey; over-the-counter medication with 500 mg acetaminophen per gelcap that’s gentle on the stomach

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$12.47

$16.59

-25%

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Amazon Basic Care

Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, Pain Reliever/Fever Reducer, 500 Count (Packaging may vary)

9.7

ChoiceComparer.com Score

9.7

/ 10

Outstanding

Main highlights

•ACTIVE INGREDIENT: Amazon Basic Care Extra Strength Pain Relief's active ingredient is Acetaminophen, 500 mg, which compares to the active ingredient of Extra Strength Tylenol CapletsAmazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, temporarily relieves minor aches and pains due to: the common cold, headache, backache, minor pain of arthritis, toothache, muscular aches, and premenstrual and menstrual cramps also temporarily reduces fever
•USE: Acetaminophen may be used as a pain reliever and fever reducer for adults and children 12 years and over
•PAIN: Pain may begin with an injury or illness, but could also originate with anything from a bad mattress to arthritisACUTE PAIN: Acute pain acts as an alarm such as with a bee sting or stubbing your toe and can last for a few moments or for longer
•Product may be manufactured in India or U.S.

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$9.58

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Amazon Basic Care

Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, Pain Reliever/Fever Reducer, 100 Count (Packaging may vary)

9.5

ChoiceComparer.com Score

9.5

/ 10

Outstanding

Main highlights

•ACTIVE INGREDIENT: This pain relief medication contains acetaminophen 500 mg, a pain reliever/fever reducer which compares to the active ingredient of Extra Strength Tylenol Caplets
•PAIN RELIEF PILLS: Temporarily relieves minor aches and pains due to the common cold, headache, backache, toothache, muscular aches, and premenstrual and menstrual cramps; also provides minor arthritis pain relief
•FEVER REDUCER: Amazon Basic Care Extra Strength Pain Relief is a fast acting-fever reducer
•EXTRA STRENGTH: Amazon Basic Care Extra Strength Pain Relief provides strong, fast-acting relief of minor aches and pains, and fever
•EASY-TO-SWALLOW CAPLETS are aspirin, caffeine and gluten free; for adults and children age 12 years and over; the package is child resistant
•Product may be manufactured in India or U.S.

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$4.06

$4.38

-7%

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Tylenol

Tylenol Sinus + Headache Daytime Non-Drowsy Relief Caplets, Acetaminophen 325mg, Nasal Decongestant for Sinus Pressure, Headache & Nasal Congestion Relief, 24 ct

9.4

ChoiceComparer.com Score

9.4

/ 10

Excellent

Main highlights

•24-count box of Tylenol Sinus + Headache Daytime Caplets for non-drowsy sinus symptom and headache pain relief due to the common cold, hay fever or other respiratory allergies
•Pain reliever and nasal decongestant formulated to temporarily reduce fever and relieve symptoms of nasal congestion, sinus headache and pressure
•Each sinus relief caplet contains 325 milligrams of acetaminophen to temporarily relieve pain and reduce fever as well as 5 milligrams of phenylephrine HCl, a nasal decongestant to help clear nasal passages
•The non-drowsy formula of this sinus medicine provides effective daytime symptom relief by promoting sinus drainage and helping to decongest sinus openings and passages
•From the #1 doctor recommended pain relief brand, these daytime headache and sinus relief caplets are suitable for adults and children ages 12 years and older for powerful daytime cold symptom relief

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$6.49

$10.67

-39%

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Tylenol

Tylenol Regular Strength Tablets with 325 mg of Acetaminophen, Fever Reducer & Pain Reliever for Headache, Backache, Muscle Aches, Joint Pain & Menstrual Cramps, 100 ct

9.2

ChoiceComparer.com Score

9.2

/ 10

Excellent

Main highlights

•100-count bottle of Tylenol Regular Strength Tablets with acetaminophen to provide temporary pain relief of minor aches and pains and help reduce fever
•Each pain relief tablet contains 325 mg of acetaminophen for effective pain relief, and has an excellent safety profile when used as directed
•Use as a fever reducer and to help alleviate common pain symptoms including headache, backache, muscle and joint pain, toothache, menstrual cramps, and pain caused by the common cold
•Regular strength 325 mg acetaminophen oral pain reliever can be used by adults & children 6+. Adults & children 12+, take 2 acetaminophen tablets every 4-6 hours while symptoms last. Children 6-11, take 1 tablet every 4-6 hours while symptoms last
•Experience effective pain relief and alleviate aches and pains with Tylenol, the #1 doctor recommended brand for pain relief and fever reduction

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$6.96

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Tylenol

Tylenol Sinus Severe Daytime Caplets with Acetaminophen 325mg, Guaifenesin 200mg & Phenylephrine HCl 5mg, Non-Drowsy Pain Reliever, Expectorant & Nasal Decongestant, 50 Travel Packs of 2 ct

9.1

ChoiceComparer.com Score

9.1

/ 10

Excellent

Main highlights

•50 travel packs of 2-ct. of Tylenol Sinus Severe Daytime Caplets for non-drowsy symptom relief due to the common cold, hay fever or other respiratory allergies such as mucus and sinus congestion. Ideal for both at home and on the go
•Pain reliever, fever reducer, decongestant and expectorant medicine temporarily relieves minor aches and pains as well as symptoms of chest congestion, nasal congestion, sinus headache and pressure
•Each caplet contains 325 milligrams of acetaminophen to reduce fever and pain; 5 milligrams of nasal decongestant phenylephrine HCl to help clear nasal passages; and 200 milligrams of the expectorant guaifenesin to help make coughs more productive
•The non-drowsy formula of this sinus medicine provides effective daytime symptom relief by promoting sinus drainage, decongesting sinus openings and passages, and thinning bronchial secretions to help make coughs more productive
•From the #1 doctor recommended pain relief brand, these severe sinus relief caplets are suitable for adults and children ages 12 years and older for powerful daytime cold symptom relief

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$21.45

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TIME-CAP LABS, INC.

TIME-CAP LABS, INC. Timely Acetaminophen 325 MG Tablets 1000 Count - Regular Strength Pain Relief - Menstrual Cramps, Fever Reducer, Minor Pain of Arthritis

8.9

ChoiceComparer.com Score

8.9

/ 10

Great

Main highlights

•Relieve Minor Aches and Pains ... Toothache? Backache? Acetaminophen relieves minor aches and pains due to headache, backache, toothache, the common cold, minor pain of arthritis, muscular aches, and premenstrual and menstrual cramps.
•Let That Fever Subside ... Dealing with a fever? Acetaminophen temporarily reduces fever, and relieves those aches and pains caused by minor pain of arthritis.
•One in Every Medicine Cabinet ... Make sure every medicine cabinet and first-aid kit has these great pain relief tablets. 1000 tablets are plenty enough to provide relief for the family.
•An Easy Way to Be Pain-Free … Find pain relief in a bottle of this Acetaminophen 325mg. Take as directed on the bottle.

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$14.50

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Belmora paracetamol

Belmora paracetamol Acetaminophen 325mg 20 Softgels for Pain Relief, Liquid Filled Capsules to Rapid Release Pain, Quick Pain Reliever for Adults Extra Strength, Fever Reducer

8.8

ChoiceComparer.com Score

8.8

/ 10

Great

Main highlights

•Liquid filled acetaminophen softgels work quickly to relieve pain!
•Effective for a Wide Range of Ailments: Relieves headaches, muscle aches, joint pain, and more, providing versatile support for daily pain.
•Acetaminophen is the most commonly used analgesic in the United States: Rigorously tested and approved for over-the-counter use, ensuring reliable results when you need them most.

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$7.99

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GeriCare

GeriCare Regular Strength Acetaminophen Pain Relief Fever Reducer Tablets, Strength 325mg Tablet | Joint, Muscle, Arthritis, Back Pain Relief 1000 Count (Pack of 1)

8.6

ChoiceComparer.com Score

8.6

/ 10

Good

Main highlights

•PAIN RELIEF: Our Gericare Acetaminophen is an analgesic medication that works by blocking pain signals to the brain, providing relief from various types of pain, including headaches, muscle aches, backaches, toothaches, and menstrual cramps. FEVER REDUCTION: Acetaminophen helps lower elevated body temperature by acting on the hypothalamus, the part of the brain that regulates body temperature. It is effective in reducing fever associated with colds, flu, and other infections.
•FAST ACTING: Acetaminophen is known for its rapid onset of action, providing quick relief from pain and fever, often within 30 to 60 minutes of ingestion. NON-ADDICTIVE: Acetaminophen is not habit-forming and does not carry the risk of dependence when used as directed. This makes it a safer option for long-term pain management.
•OVER-THE-COUNTER AVAILABILITY: Acetaminophen is available without a prescription, making it easily accessible for individuals seeking relief from pain and fever without needing to visit a healthcare provider. LOW INCIDENCE OF SIDE EFFECTS: When taken at recommended doses, acetaminophen is generally well-tolerated by most individuals. It has a lower risk of causing gastrointestinal irritation compared to nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or aspirin.
•SUITABLE FOR VARIOUS AGES: Acetaminophen can be used by adults, children, and older adults, making it suitable for individuals of different ages. However, dosage adjustments may be necessary for children based on their weight or age. SAFE FOR PREGNANCY AND BREASTFEEDING: Acetaminophen is considered safe to use during pregnancy and while breastfeeding when taken at recommended doses. It is often recommended as a first-line treatment for pain and fever in pregnant individuals.
•MINIMAL DRUG INTERACTIONS: Acetaminophen has fewer interactions with other medications compared to NSAIDs, making it a safer option for individuals taking multiple medications or those with pre-existing medical conditions.

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$20.99

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Tylenol

Tylenol Reg Strngth 100'S Size 100ct Tylenol 325 Mg Regular Strength Pain Reliever

8.5

ChoiceComparer.com Score

8.5

/ 10

Good

Main highlights

•Product of TYLENOL
•Pack of 3

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$35.41

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