Top 10 Best tylenol pm sleep aid in 2026

Last Updated - 7/5/2026

🏆Best Choice

Tylenol

Tylenol PM Extra Strength Nighttime Pain Reliever & Sleep Aid Caplets, 500 mg Acetaminophen & 25 mg Diphenhydramine HCl, Relief for Nighttime Aches & Pains, Non-Habit Forming, 24 ct

9.8

ChoiceComparer.com Score

9.8

/ 10

Outstanding

Main highlights

•24-count bottle of Tylenol PM Extra Strength Caplets Nighttime Pain Reliever & NonHabit Forming Sleep Aid to provide minor pain relief and help you fall asleep fast
•Relieve nighttime pain and get the sleep you need with 25 mg diphenhydramine HCl and 500 mg acetaminophen per caplet. This nighttime sleep aid and pain relief medicine is non-habit forming when used as directed
•Fall asleep fast and stay asleep and relieve minor pain with this nighttime sleep aid and pain relief medicine from the #1 doctor-recommended brand for pain relief and fever reduction
•This pain relief sleep aid is intended for use by adults and children who are 12 years of age and older, and is not suitable for younger children or babies
•With Tylenol PM Extra Strength Caplets Pain Reliever plus Sleep Aid, we give you a better night. So you're a better you all day

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$5.49

$7.99

-31%

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Tylenol

Tylenol PM Extra Strength Nighttime Pain Reliever & Sleep Aid Caplets, 500 mg Acetaminophen & 25 mg Diphenhydramine HCl, Relief for Nighttime Aches & Pains, Non-Habit Forming, 100 ct

9.7

ChoiceComparer.com Score

9.7

/ 10

Outstanding

Main highlights

•100-count bottle of Tylenol PM Extra Strength Caplets Nighttime Pain Reliever & NonHabit Forming Sleep Aid to provide minor pain relief and help you fall asleep fast
•Relieve nighttime pain and get the sleep you need with 25 mg diphenhydramine HCl and 500 mg acetaminophen per caplet. This nighttime sleep aid and pain relief medicine is non-habit forming when used as directed
•Fall asleep fast and stay asleep and relieve minor pain with this nighttime sleep aid and pain relief medicine from the #1 doctor-recommended brand for pain relief and fever reduction
•This pain relief sleep aid is intended for use by adults and children who are 12 years of age and older, and is not suitable for younger children or babies
•With Tylenol PM Extra Strength Caplets Pain Reliever plus Sleep Aid, we give you a better night. So you're a better you all day

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$13.97

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Tylenol

Tylenol PM Extra Strength Nighttime Pain Reliever & Sleep Aid Caplets, 500 mg Acetaminophen & 25 mg Diphenhydramine HCl, Relief for Nighttime Aches & Pains, Non-Habit Forming, 150 ct

9.5

ChoiceComparer.com Score

9.5

/ 10

Outstanding

Main highlights

•150-count bottle of Tylenol PM Extra Strength Caplets Nighttime Pain Reliever & NonHabit Forming Sleep Aid to provide minor pain relief and help you fall asleep fast
•Relieve nighttime pain and get the sleep you need with 25 mg diphenhydramine HCl and 500 mg acetaminophen per caplet. This nighttime sleep aid and pain relief medicine is non-habit forming when used as directed
•Fall asleep fast and stay asleep and relieve minor pain with this nighttime sleep aid and pain relief medicine from the #1 doctor-recommended brand for pain relief and fever reduction
•This pain relief sleep aid is intended for use by adults and children who are 12 years of age and older, and is not suitable for younger children or babies
•With Tylenol PM Extra Strength Caplets Pain Reliever plus Sleep Aid, we give you a better night. So you're a better you all day

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$19.97

$26.59

-25%

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Amazon Basic Care

Amazon Basic Care Acetaminophen PM Caplets, Pain Reliever Plus Nighttime Sleep Aid, Extra Strength, Helps Occasional Minor Aches, Pains and Headache Relief, 100 Count, Packaging may vary

9.4

ChoiceComparer.com Score

9.4

/ 10

Excellent

Main highlights

•ACTIVE INGREDIENTS: The active ingredients in Amazon Basic Care Acetaminophen PM are acetaminophen 500 mg, pain reliever, and diphenhydramine HCl 25 mg, nighttime sleep aid. Compare to Extra Strength Tylenol PM Caplets active ingredients
•LESS PAIN, MORE SLEEP: Minor aches & pains can interfere with restful sleep. Amazon Basic Care Acetaminophen PM has 500 mg acetaminophen, pain reliever, and 25 mg of diphenydramine hydrochloride, nighttime sleep aid, together in easy-to-swallow caplets
•USE: Amazon Basic Care Acetaminophen PM may be used as a pain reliever and nighttime sleep aid for adults and children 12 years and over. Child-resistant cap.
•EFFECTIVE SLEEP AID: For pain with sleeplessness. Relieve minor pain with extra-strength Amazon Basic Care Acetaminophen PM nighttime sleep aid medicine which is aspirin free and gluten free.
•NON-HABIT FORMING: Extra strength Amazon Basic Care Acetaminophen PM Caplets are non-habit forming when used correctly.

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$5.97

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HealthA2Z

HealthA2Z® Extra Strength Pain Relief PM| Acetaminophen 500mg | Diphenhydramine 25mg | Pain Reliever & Nighttime Sleep Aid | (365 Count (Pack of 1))

9.2

ChoiceComparer.com Score

9.2

/ 10

Excellent

Main highlights

•500 mg Acetaminophen, a proven pain reliever, helps relieve muscle, joint, headache, and arthritis pain quickly.
•25 mg Diphenhydramine, a gentle, non-habit-forming sleep aid, helps you fall asleep and stay asleep while also relieving fever and minor aches and pain with the help of Acetaminophen.
•It contains NO Aspirin
•Adults and children 12 years and over: take 2 caplets at bedtime. Do not take more than 2 caplets of this product per 24 hours/ Children under 12 years do not use.
•No gluten added product

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$14.95

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Tylenol

Tylenol Simply Sleep Nighttime Sleep Aid Caplets, 25 mg Diphenhydramine HCl, Non-Habit Forming Sleep Aid for Adults, 100 Count

9.1

ChoiceComparer.com Score

9.1

/ 10

Excellent

Main highlights

•100-count bottle of Simply Sleep Nighttime Sleep Aid to help relieve occasional sleeplessness by easing you into sleep so you wake up feeling refreshed and ready for your day
•Each caplet of this adult sleep aid contains 25 mg of diphenhydramine hydrochloride as the active ingredient and can be used by adults and children ages 12 years and older
•From the makers of Extra Strength Tylenol PM, Simply Sleep can help you fall asleep when pain isn't what is keeping you up
•Simply Sleep can be used for the relief of occasional sleeplessness this nighttime sleep aid is non-habit forming when used as directed
•Dream a little dream and get a restful night's sleep with this nighttime sleeping aid that helps you fall asleep quickly
•Adults and children over 12 years and over can take 2 caplets at bedtime if needed or as directed by a doctor
•This nighttime adult sleep aid helps you get to sleep and stay asleep
•For safe storage of this sleep aid medication, we recommend putting up and away after every use and keeping products out of sight of young children
•Adults and children over 12 years and over can take 2 caplets at bedtime if needed or as directed by a doctor
•This nighttime adult sleep aid helps you get to sleep and stay asleep
•For safe storage of this sleep aid medication, we recommend putting up and away after every use and keeping products out of sight of young children

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$14.99

$20.37

-26%

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RIGHT REMEDIES

Right Remedies Extra Strength Pain Relief PM & Nighttime Sleep Aid Caplets,(300 count), Acetaminophen 500 mg & Diphenhydramine HCl 25 mg, Non-Habit Forming, Compare to Active ingredients of Tylenol PM

8.9

ChoiceComparer.com Score

8.9

/ 10

Great

Main highlights

•✅ ACETAMINOPHEN 500 MG : Formulated with active ingredient acetaminophen for temporary relief of minor aches and pains due to: the common cold, headache, backache, minor pain of arthritis, toothache, muscular aches, and premenstrual and menstrual cramps
•✅ DIPHENHYDRAMINE HCL 25 MG : Nighttime Pain Reliever & NonHabit Forming Sleep Aid to provide minor pain relief and help you fall asleep fast when used as directed
•✅ EXTRA STRENGTH PAIN RELIEF : Contains 500 mg of acetaminophen is effective, lasting pain reliever and 25 mg of diphenhydramine HCl, is a nighttime sleep aid.
•✅ EASY TO SWALLOW : RIGHT REMEDIES PM Extra Strength Nighttime Pain Reliever Caplets are easy-to-swallow
•✅ COMPARE TO : Active ingredients in Extra Strength Tylenol PM Caplets
•✅ DIRECTIONS : Adults and children 12 years of age and over: take 2 caplets at bedtime. Do not take more than 2 caplets of this product in 24 hours

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$10.99

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GenCare

GenCare Extra Strength Acetaminophen PM 500 mg (375 Tablets) | Ultimate Pain Relief & Sleep Support for Adults | Quick Acting & Non Habit Forming Headache Relief | Eases Aches & Joint Discomfort

8.8

ChoiceComparer.com Score

8.8

/ 10

Great

Main highlights

•PM PAIN RELIEF - Acetaminophen (generic Tylenol) is the fast acting pain reliever for people suffering from headaches, migraines, sore muscles, joint pain, inflammation, toothaches, menstrual cramps, back aches and common cold and flu symptoms. 1 pill contains 500 milligrams of Acetaminophen.
•NIGHTTIME FORMULA - Our PM sleep aid formula contains 25 mg of Diphenhydramine to help you fall asleep faster and stay asleep longer. This non habit forming sleep aid and pain relief medication is helpful for people whose symptoms are keeping them up at night or causing restlessness or insomnia.
•BULK SAVINGS BOTTLE - Enjoy always having PM formulated Acetaminophen at hand for you and your family. Each bulk value bottle contains 375 tablets which is great for families and busy households who need fast acting relief and want to save money by purchasing generic extra strength tablets in bulk.
•EXTRA STRENGTH - The combination of 500 mg Acetaminophen and 25 mg of Diphenhydramine combine to give you fast acting aches and pain relief. Diphenhydramine sleep aid also acts as an antihistamine to reduce allergy symptoms and common cold symptoms like congestion and coughing itchy throat. Sleeping is essential to recovery and wellness.

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$14.99

$17.99

-17%

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Tylenol

Tylenol PM Extra Strength Nighttime Pain Reliever & Sleep Aid Caplets, 500 mg Acetaminophen & 25 mg Diphenhydramine HCl, Relief for Nighttime Aches & Pains, Non-Habit Forming, 50 ct

8.6

ChoiceComparer.com Score

8.6

/ 10

Good

Main highlights

•50-count bottle of Tylenol PM Extra Strength Caplets Nighttime Pain Reliever & Non-Habit Forming Sleep Aid to provide minor pain relief and help you fall asleep fast
•Relieve nighttime pain and get the sleep you need with 25 mg diphenhydramine HCl and 500 mg acetaminophen per caplet. This nighttime sleep aid and pain relief medicine is non-habit forming when used as directed
•Fall asleep fast and stay asleep and relieve minor pain with this nighttime sleep aid and pain relief medicine from the #1 doctor-recommended brand for pain relief and fever reduction
•This pain relief sleep aid is intended for use by adults and children who are 12 years of age and older, and is not suitable for younger children or babies
•With Tylenol PM Extra Strength Caplets Pain Reliever plus Sleep Aid, we give you a better night. So you're a better you all day

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$12.44

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Tylenol

Tylenol Pm ES Caplet 24ct Size 24ct

8.5

ChoiceComparer.com Score

8.5

/ 10

Good

Main highlights

•Product of TYLENOL
•Pack of 6

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$7.49

$7.99

-6%

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