Top 10 Best oral pain relief in 2026

Last Updated - 7/2/2026

🏆Best Choice

Orajel

Orajel Baby Daytime & Nighttime Cooling Gels for Teething, Drug - Free, #1 Pediatrician Recommended Brand for Teething*, Two 0.18oz Tubes

9.8

ChoiceComparer.com Score

9.8

/ 10

Outstanding

Main highlights

•HELPS CALM, RELAX AND SOOTHE: Our instant cooling sensation works wonders on infants who may be teething, upset, cranky or fussy – day or night
•DRUG-FREE: Free from benzocaine, belladonna, eugenol, sugar, menthol, sodium lauryl sulfate (SLS), sulfate, dairy, and artificial colors, dyes, and sweeteners
•SAFE AND GENTLE FORMULA: Both our daytime and nighttime cooling gels are easy-to-use at home or away
•#1 PEDIATRICIAN RECOMMENDED: Trust the professionals who trust Orajel Baby
•STAGE 1 FOR AGES 0+: Orajel Kids Stage 1 Teething and Tooth & Gum Cleanser products are appropriate for ages 0 and up
•easy to use, easy to soothe with an instant cooling sensation
•When it’s time to move on to fluoride-free training toothpaste and independent brushing, Orajel has you covered from first tooth to full smile.

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$5.94

$7.99

-26%

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Orajel

Orajel Baby Nighttime Cooling Gel for Teething, Drug-Free, #1 Pediatrician Recommended Brand for Teething*, One .18oz Tube

9.7

ChoiceComparer.com Score

9.7

/ 10

Outstanding

Main highlights

•HELPS CALM, RELAX AND SOOTHE: Our instant cooling sensation works wonders on infants who may be teething, upset, cranky, or fussy
•DRUG-FREE: Free from benzocaine, belladonna, eugenol, sugar, menthol, sodium lauryl sulfate (SLS), sulfate, dairy, and artificial colors, dyes, and sweeteners
•SAFE AND GENTLE FORMULA: Our nighttime cooling gel with chamomile is easy-to-use at home or away
•#1 PEDIATRICIAN RECOMMENDED: Trust the professionals who trust Orajel Baby
•STAGE 1 FOR AGES 0+: Orajel Kids Stage 1 Teething and Tooth & Gum Cleanser products are appropriate for ages 0 and up.

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$7.00

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Anbesol

Anbesol Maximum Strength Oral Pain Relief Gel, Instant Pain Relief For Toothache Pain, Canker Sores, Sore Gums, Mouth Sores, Denture Pain, and Aligner Pain, ADA Accepted, 0.33 oz (packaging may vary)

9.5

ChoiceComparer.com Score

9.5

/ 10

Outstanding

Main highlights

•INSTANT ORAL PAIN RELIEF: Anbesol Maximum Strength Gel for mouth pain, including toothache pain, canker sores, sore gums, mouth sores, denture pain, braces, retainer and aligner pain, and minor dental procedures
•OW to WOW INSTANTLY: Formulated with the active ingredient Benzocaine, an oral pain reliever, and numbs instantly to temporarily relieve toothaches, gum pain, canker sores and aligner pain
•GEL FORMULA: Anbesol Gel Formula goes on clear and is undetectable, stays where you apply it, and provides fast and effective numbing of oral pain
•ADA ACCEPTED: Accepted by the American Dental Association and has shown efficacy to help temporarily relieve discomfort of mouth sores
•CONVENIENT: Take the tiny Anbesol gel tube with you for oral pain relief on-the-go up to 4x daily. For adults and children 2 years and older with adult supervision. Use as directed

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$6.74

$7.99

-16%

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Orajel

Orajel 3X for Mouth Sores: Maximum Strength Gel Tube 0.42oz- From #1 Oral Pain Relief Brand

9.4

ChoiceComparer.com Score

9.4

/ 10

Excellent

Main highlights

•INSTANT PAIN RELIEF: Orajel Mouth Sore Gel contains 20% Benzocaine to relieve pain from canker sores, mouth sores, cold sores and other mouth irritations
•SOOTHING RELIEF: Maximum strength gel uses menthol to soothe irritated and sore gums quickly, where you need it most
•PROTECTION: Our unique, fast acting, formula contains an astringent to help protect sores from irritation, including irritation from dentures or braces, as well as canker sores
•EASY OPEN: Now with a Ready-Open Tube Tip for easy access to the relief you need. A convenient remedy for use at home or on the go.
•From the #1 Oral Pain Reliever Brand for Adults

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$6.54

$8.99

-27%

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Anbesol

Anbesol Maximum Strength Liquid, Instant Oral Pain Relief For Toothaches, Mouth Sores*, Gum, Braces & Denture Pain, ADA Accepted, 0.41 oz

9.2

ChoiceComparer.com Score

9.2

/ 10

Excellent

Main highlights

•Instant Oral Pain Relief: Anbesol Maximum Strength Liquid for mouth pain, including toothache pain, canker sores, sore gums, mouth sores, denture pain, braces, retainer and aligner pain, and minor dental procedures
•OW to WOW! Instantly: Formulated with the active ingredient Benzocaine, an oral pain reliever, and numbs instantly to temporarily relieve toothaches, gum pain, canker sores and aligner pain.
•Liquid Formula: Anbesol Liquid Formula goes on clear and is undetectable, stays where you apply it, and provides fast and effective numbing of oral pain
•ADA Accepted: Accepted by the American Dental Association and has shown efficacy to help temporarily relieve discomfort of mouth sores
•Convenient: Take the tiny Anbesol gel tube with you for oral pain relief on-the-go up to 4x daily. For adults and children 2 years and older with adult supervision. Use as directed

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$6.59

$7.99

-18%

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Orajel

Orajel Nonseptic Mouth Sore Rinse 16oz, Soothing Mint Flavor, Provides Pain Relief, Promotes Healing, 3-Pack

9.1

ChoiceComparer.com Score

9.1

/ 10

Excellent

Main highlights

•PAIN RELIEF: Orajel Mouthwash helps to provide you with temporary pain relief from your mouth sores and irritation.
•PROMOTES HEALING: Specially formulated to help kill bacillus in your mouth and promote healing so you can feel better.
•FOR ALL MOUTH SORES: From canker sores, to cheek bites, gum irritation, and sores from dentures or braces- Orajel Mouth Sore Rinse can help alleviate your pain from the comfort of your home.
•MINT FLAVOR mouthwash, 16oz
•#1 Oral Pain Reliever Brand for Adults

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$22.17

$28.67

-23%

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Orajel

Orajel Maximum Strength Nighttime Toothache Pain Relief Cream - 0.25 Oz

8.9

ChoiceComparer.com Score

8.9

/ 10

Great

Main highlights

•B00433JHW2

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$7.48

$8.29

-10%

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Orajel

Orajel 4X for Toothache & Gum Pain: Severe Cream Tube 0.33oz- From Oral Pain Relief Brand

8.8

ChoiceComparer.com Score

8.8

/ 10

Great

Main highlights

•INSTANT PAIN RELIEF: Instant pain relief with Orajel’s unique 4X clinical strength formula to help relieve pain of the tooth and gums
•4X ACTIVE INGREDIENTS: With 4 active ingredients, Orajel Cream provides fast acting and maximum strength relief when you need it most
•KILLS HARMFUL BACTERIA: Unique formula is designed to help kill harmful bacteria in the mouth, and can help to prevent infections
•COOLING RELIEF: To help relieve gum irritation, Orajel 4X cream contains cooling relief
•EASY OPEN: Now with a Ready-Open Tube Tip for easy access to the relief you need. A convenient remedy for use at home or on the go.

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$7.48

$9.99

-25%

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Orajel

Orajel 3X for Toothache & Gum Pain: Maximum Gel Tube 0.42oz - From #1 Oral Pain Relief Brand - Orajel for Instant Pain Relief

8.6

ChoiceComparer.com Score

8.6

/ 10

Good

Main highlights

•INSTANT PAIN RELIEF: Instant pain relief with Orajel’s maximum strength formula to help relieve pain of the tooth and gums with 20% benzocaine
•KILLS HARMFUL BACTERIA: Unique formula is designed to help kill harmful bacteria in the mouth, and can help to prevent infections
•COOLING RELIEF: To help relieve gum irritation, Orajel toothache gel contains cooling relief
•EASY OPEN: Now with a Ready-Open Tube Tip for easy access to the relief you need. A convenient remedy for use at home or on the go
•From the Oral Pain Reliever Brand for Adults

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$6.98

$7.39

-6%

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Iodent

ORAL ANALGESIC GEL 0.42 OZ

8.5

ChoiceComparer.com Score

8.5

/ 10

Good

Main highlights

•Iodent Compare to the active ingredient of ORAJEL
•ORAJEL

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$5.19

$5.99

-13%

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📈 How we rank

With our cutting-edge technology, we examine thousands of products and retailers, assessing reviews, ratings, trends, and sales rankings to identify what matters most to users like you.

Our team evaluates this data alongside genuine user feedback, merging AI analysis with human insights to provide you with real-time, highly-rated recommendations that empower your decision-making with clarity and confidence.