Top 10 Best hand sanitizer big bottle in 2026

Last Updated - 6/23/2026

🏆Best Choice

Germ-X

Germ-X Advanced Hand Sanitizer with Aloe and Vitamin E, Non-Drying Moisturizing Gel, Instant and No Rinse Formula, Pump Bottle, Back to School Supplies, 1 Liter

9.8

ChoiceComparer.com Score

9.8

/ 10

Outstanding

Main highlights

•Back To School Essential: Go for the A+! Germ-X kills 99.99% of germs* and leaves hands feeling refreshed, making it a must-have for every classroom, lunchbox and backpack
•Fast and Effective: Cleaning on the go just got a lot easier. Germ-X Advanced Aloe Hand Sanitizer gel kills 99.99% of germs without water in as little as 15 seconds
•Moisturizing Hand Sanitizer: This pleasant, fresh-smelling and non-drying sanitizing formula is enriched with Aloe and Vitamin E, leaving skin feeling soft and moisturized with no sticky residue
•Clear Gel Formula: This USP-grade alcohol-based liquid hand sanitizer is the perfect convenient alternative to soap and water to leave your hands feeling smooth and fresh
•X Germs with Confidence: We make Germ-X products that go wherever you go. From convenient pumps, flip-top caps, sprays, and even wipes, Germ-X products have you covered
•Formula Made in the USA: The makers of Germ-X products have been helping happy, healthy families since 1997

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$5.82

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Germ-X

Germ-X Advanced Hand Sanitizer, Non-Drying Moisturizing Clear Gel, Instant and No Rinse Formula, Large Family Size Pump Bottle, Back to School Supplies, 34 Fl Oz (1 Liter)

9.7

ChoiceComparer.com Score

9.7

/ 10

Outstanding

Main highlights

•Back To School Essential: Go for the A+! Germ-X kills 99.99% of germs* and leaves hands feeling refreshed, making it a must-have for every classroom, lunchbox and backpack
•Fast and Effective: Hand sanitizing on the go just got a lot easier. Germ-X Advanced Hand Sanitizer gel with aloe kills 99.99% of many common germs without water in as little as 15 seconds
•Moisturizing Hand Sanitizer: This pleasant, fresh-smelling and non-drying hand sanitizing formula is enriched with moisturizers to help leave skin feeling soft and moisturized with no sticky residue
•Clear Gel Formula: This USP-grade 70% alcohol-based hand sanitizer is the perfect convenient alternative to soap and water. The less-drying formula leaves your hands feeling smooth and smelling great
•X Germs with Confidence: We make Germ-X products that go wherever you go. From convenient pumps, flip-top caps, sprays, and even wipes, Germ-X products have you covered
•Formula Made in the USA: The makers of Germ-X products have been helping happy, healthy families since 1997

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$5.82

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Amazon Basic Care

Amazon Basic Care - Aloe Vera Hand Sanitizer 62%, 12 fl oz (Pack of 6)

9.5

ChoiceComparer.com Score

9.5

/ 10

Outstanding

Main highlights

•CONVENIENT PACKAGING: Includes 6 bottles, hand sanitizer bulk supply
•ALOE VERA INFUSED: Enriched with Aloe Vera, this hand sanitizer with aloe keeps your hands soft and moisturized
•VITAMIN E: Contains Vitamin E, gentle hand sanitizer gel formula
•ALCOHOL CONTENT: This hand sanitizer gel features 62% Ethyl Alcohol

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$13.83

$15.85

-13%

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GOJO

PURELL 365912EA Advanced Instant Hand Sanitizer, 12oz Pump Bottle

9.4

ChoiceComparer.com Score

9.4

/ 10

Excellent

Main highlights

•Sold as 1 Each.
•Stay clean without soap or water! Kills 99.99% of the most common, illness-causing germs.
•Specially formulated with moisturizers to leave hands soft and refreshed.
•Alcohol-based formula.

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$9.99

$13.04

-23%

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Germ-X

Germ-X Original Hand Sanitizer, Fast-Drying Moisturizing Gel with Vitamin E, Instant & No Rinse Formula, 62% Alcohol, Back to School Supplies, Bulk Size Pump Bottle, 67.6 Fl Oz (Pack of 1)

9.2

ChoiceComparer.com Score

9.2

/ 10

Excellent

Main highlights

•Back To School Essential: Go for the A+! Germ-X kills 99.99% of germs* and leaves hands feeling refreshed, making it a must-have for every classroom, lunchbox and backpack
•Fast and Effective: Germ-X Hand Sanitizer Gel kills 99.99% of germs without water in as little as 15 seconds*. This large hand sanitizer with pump ensures easy release, reduced spills & mess, and an ample supply to keep up with frequent long-term use
•Moisturizing Hand Sanitizer: This pleasant, fresh-smelling and fast-drying sanitizing formula is enriched with Vitamin E, leaving skin feeling smooth and moisturized with no sticky residue
•Clear Gel Formula: This USP-grade alcohol-based liquid hand sanitizer is the perfect convenient option when soap and water are unavailable to leave your hands feeling smooth and fresh
•X Germs with Confidence: We make Germ-X products that go wherever you go. From convenient pumps, flip-top caps, sprays, and even wipes, Germ-X products have you covered

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$17.98

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Purell

PURELL Advanced Hand Sanitizer Refreshing Gel, Clean Scent, 1 Liter Pump Bottle (Pack of 1) - 9632-04-CMR

9.1

ChoiceComparer.com Score

9.1

/ 10

Excellent

Main highlights

•Show you care about well-being with PURELL Advanced Hand Sanitizer Refreshing Gel, which eliminates 99.99 percent of germs on hands
•Features a refreshing clean scent and evaporates quickly for easy, convenient sanitizing when soap and water aren’t available
•Mild formula and a blend of four moisturizers means hands feel soft even with frequent use; it’s free of triclosan, parabens, phthalates, and preservatives so it doesn’t dry out or irritate skin
•Place these 1-Liter PURELL pump bottles in high-traffic areas where frequent hand sanitization is needed, including classrooms, office reception areas, breakrooms, and large indoor or outdoor events
•Case Includes: 1 – PURELL Advanced Hand Sanitizer Refreshing Gel for Workplaces, 1-Liter pump bottle

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$13.40

$15.99

-16%

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Amazon Basics

Amazon Basics Hand Sanitizer, Original Scent, Contains 62% Ethyl Alcohol, 67.60 Fl Oz (Pack of 1) (Previously Solimo

8.9

ChoiceComparer.com Score

8.9

/ 10

Great

Main highlights

•One 67.6-fluid ounce bottle of 62% ethyl alcohol hand sanitizer
•Active Ingredient: 62% Ethyl Alcohol
•Moisturizers leave hands feeling smooth
•Original scent
•If you like Germ-X Moisturizing Hand Sanitizer, we invite you to try Amazon Basics Hand Sanitizer
•Alexa voice shopping enabled: to place your next order, just say, “Alexa Utternace"

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$13.60

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Amazon Basic Care

Amazon Basic Care - Original Hand Sanitizer 62%, 34 fl oz (Pack of 4)

8.8

ChoiceComparer.com Score

8.8

/ 10

Great

Main highlights

•Four 34-fluid ounce bottles of hand sanitizer
•62% Ethyl Alcohol
•With Vitamin E
•Original scent
•An Amazon brand

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$30.14

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PURELL

PURELL Advanced Hand Sanitizer Naturals with Plant-Based Alcohol, Citrus scent, 1 Liter Pump Bottle (Pack of 1) - 3280-04-CMR

8.6

ChoiceComparer.com Score

8.6

/ 10

Good

Main highlights

•Help your family and those you care about kill germs on their hands with PURELL Advanced Hand Sanitizer Naturals, made with naturally derived alcohol
•Proven to kill germs with 2x sanitizing strength
•ECOLOGO certified with essential oils and natural skin conditioners and is free of triclosan, parabens, phthalates, and other unnecessary ingredients
•Large one-liter bottle is ideal for frequent hand sanitizing, like in homes, schools, and offices—or use it to refill PURELL Aluminum Hand Sanitizer Bottles (sold separately, SKU 3282-12KIT-EC)
•Case Includes: (1) 1 Liter PURELL Advanced Hand Sanitizer Naturals with Pump Included
•PURELL Advanced Hand Sanitizer is proven effective through tests conducted by independent third-party laboratories on real hands. Trust in our science-based products.

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$16.41

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Purell

Purell Advanced Hand Sanitizer Refreshing Gel, Clean Scent, 1.5 Liter Pump Bottle (Pack of 1) - 5015-04

8.5

ChoiceComparer.com Score

8.5

/ 10

Good

Main highlights

•Show you care with PURELL Advanced Hand Sanitizer Refreshing Gel, America’s hand sanitizer; just one squirt kills as many germs as two squirts of any other national brand
•Offering PURELL products can positively impact your business image. In fact, 84% of people expect hand sanitizer to be offered in public places
•Mild formula and a blend of four skin conditioners means hands feel soft even with frequent use; it's free of triclosan, parabens, phthalates, and preservatives, so it's gentle on skin
•Place these 1.5 liter PURELL pump bottles in high-traffic areas where frequent hand sanitization is needed, including classrooms, office reception areas, breakrooms, and outdoor events
•Case Includes: 1 – PURELL Advanced Hand Sanitizer Refreshing Gel, 1.5 Liter pump bottles
•PURELL Advanced Hand Sanitizer is proven effective through tests conducted by independent third-party laboratories on real hands. Trust in our science-based products.

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$21.99

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With our cutting-edge technology, we examine thousands of products and retailers, assessing reviews, ratings, trends, and sales rankings to identify what matters most to users like you.

Our team evaluates this data alongside genuine user feedback, merging AI analysis with human insights to provide you with real-time, highly-rated recommendations that empower your decision-making with clarity and confidence.